Secretariat of the Regional Representatives Council (DPRD) has the task of organizing the administration of secretarial, financial administration, supporting the implementation of the works and functions of Parliament, and providing and coordinating expertise required by Parliament in accordance with the financial capacity of the region , is now seen to various constraints faced by employees regarding performance. Should be a study with the title "Effect of Spiritual Motivation, Psychology and Physiology of Performance Against the Religious With Job Satisfaction As Intervening, "The population of this study were all employees of the secretariat of Parliament amounted to 166 people, with methods census, the community used as a sample, Data analysis was performed using the Structural Equation Model (SEM). The software used for the structural analysis is AMOS version 23 of the Arbuckle, and for descriptive study using SPSS version 23, the research results are as follows:Pengaruh variables influence motivation Spiritual variable job satisfaction is positively significant, Effect of variable Psychology against the variable job satisfaction is negatively insignificant, effect of variable Physiology on Job Satisfaction is positively negligible, Effect of variable Motivation Spiritual to the variable performance of Religious Undoubtedly significant, Effect of variable psychology of the variable performance of Religious positively insignificant, effect of variable Physiology to the variable performance of Religious is undeniably substantial, Effect of variable Motivation Spiritual, psychology and Physiology together on Job Satisfaction is Undoubtedly negligible, Spiritual Motivation influences influence variables Job Satisfaction to the variable performance of Religious positive not significant, Changes in job satisfaction, Psychology and Physiology of 41.5%, a change of Spiritual Motivation religious influences performance, Psycholo