Education at higher education institutions need support in particular of human resources facilitateso that the educational process can run well. Lecturer highly affects the quality of the lecture and the output generated by the higher education institution. To achieve this, the lecturer is desirable social sensitivity and academic competence in transforming the existing science to his students. The purpose of this research is to know the influence of organizational culture on performance through Total Quality Management(TQM)and involves Management Information Systems(MIS)as moderating variable. The